20% Mannitol Injection USP is a sterile, nonpyrogenic solution of Mannitol USP in a single dose container for intravenous administration. It contains no antimicrobial agents. Mannitol is 6-carbon sugar alcohol prepared commercially by the reduction of dextrose. Although virtually inert metabolically in humans, it occurs naturally in fruits and vegetables. Mannitol is an obligatory osmotic diuretic.
20% Mannitol Injection USP is indicated for:
- Promotion of diuresis, in the prevention and/or treatment of the oliguric phase of acute renal failure before irreversible renal failure becomes established
- Reduction of intracranial pressure and treatment of cerebral edema by reducing brain mass
- Reduction of elevated intraocular pressure when the pressure cannot be lowered by other means
- Promotion of urinary excretion of toxins