Magnavit capsule

Pharmacological Category:

Magnavit is a nutritional supplement containing minerals, multivitamins and trace elements.

Pharmacological Action:

Magnavit contains vitamins and dietary minerals which are fundamentally involved in vital metabolic processes, where they serve as oxidising or reducing agents and as co-factors in various enzyme systems These essential micronutrients are so closely interrelated that the lack of anyone of them may affect the body requirements of others.

Vitamin A is essential for the production and regeneration of visual purple of retina, for maintenance of integrity of epithelial tissues. Vitamins B-complex usually function as co-enzyme in carbohydrate, protein and amino acid metabolism, DNA synthesis, maturation of RBCs, nerve cell function. Vitamin C facilitates absorption of iron and wound healing.

Vitamin D3 is essential for the growth of bone through regulation of calcium absorption. Calcium D Pantothenate is a component of coenzyme A which is essential in the metabolism of carbohydrate, fat and protein. Nicotinamide plays a vital role in metabolism of proteins essential for tissue respiration.

Calcium is used as a dietary supplement. It is essential for the maintenance of normal bone and calcium salts may be indicated in the treatment of bone disorders. Phosphorus plays a dynamic role in energy metabolism, modifies the tissue concentrations of calcium ions and plays a major role in renal excretion of hydrogen ions. Certain peptidases and phosphatases require Magnesium for maximal activity. Iron is required as a component of haemoglobin in Red Blood Cells.

Manganese is an essential trace element activates numerous enzyme systems including those involved with glucose metabolism, energy production. It is a major constituent of several metalloenzymes, hormones and proteins of humans. Copper is required in the formation of hemoglobin, red blood cells as well as bones, while it helps in the formation of elastin and collagen necessary for wound healing. Zinc is necessary for a healthy immune system, needed for cell division, and is needed by the tissue of the hair, nails and skin to be in top form.

Zinc is further used in the growth and maintenance of muscles, Potassium is essential for many metabolic and physiological processes including nerve conduction, muscle contraction and acid-base regulation. Iodine is used in the production of hormones (such as thyroxine, thyroxin) by the thyroid gland, which in turn regulates the conversion of fat to energy, stabilizing our body weight as well as controlling our cholesterol levels.

Pharmacokinetic Properties:

Vitamin A is a fat soluble vitamin and is readily absorbed from the normal gastrointestinal tract. Plasma concentrations reach a peak level within 3 to 5 hours. Beta-carotene is converted to retinal, which is mostly reduced to retinol and conjugated with glucuronic acid and excreted in the urine and feces. Some retinol is esterified mainly to retinyl palmitate. Normal plasma concentration is approximately 1.4

Magnavit contains adequate concentration of an essential vitamins and minerals to meet usual and increased demands of the body for periods of active growth, convalescence, pregnancy, lactation, nutritional deficiency states and stressful conditions. Thus, Magnavit provides vitamins and minerals needed for blood and body building.

Magnavit is contraindicated in conditions of haemochromatosis and haemosiderosis.

Caution:

Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately. The use of Nicotinamide containing preparations in patients with gastritis, peptic ulcers or asthma should be undertaken carefully.

Iron deficiency anaemia may be a manifestation of chronic disease which should be detected and treated if possible. Excessive doses of Vitamin A should be avoided in pregnancy because of potential teratogenic effects. Lactating women should not take vitamin D if possible, as this may lead to the development of hypercalcaemia in the infant.

Usage in Pregnancy & Lactation:

It can be given during pregnancy & lactation, however in case of anemia, therapeutic dose of iron should be given along with folic acid

Oral iron preparations interfere with absorption of oral tetracyclines, these products should be taken within two hours of each other. Mineral reduces absorption of fat soluble Vitamins such as A and D. Ascorbic acid may decrease the hypoprothrombinaemia effect of oral anticaogulants. Prothrombin level should be monitored.

Vitamin A: Absorbtion of vitamin A from the gastro-intestinal tract may be reduced by the presence of neomycin, cholestyramine, or liquid paraffin; absorption may also be impaired in cholestatic jaundice and fat-malabsorption conditions.

Vitamin B6: Reduces the effects of levodopa. The effects of Vitamin D may be reduced in patients taking barbiturates or anticonvulsants

Effects on ability to drive and operate machinery: Not applicable.

Oral route. Unless otherwise prescribed by the medical practitioner, one capsule per day to be taken at the main meal.

Caution: The use of Nicotinamide containing preparations in patients with gastritis, peptic ulcers or asthma should be undertaken carefully. Iron deficiency anaemia may be a manifestation of chronic disease which should be detected and treated if possible.

Symptoms of over dosage & its treatment:

Massive overdosage may cause gastro­intestinal upsets which will disappear on withdrawal of the product. Overdosage over long periods with Vitamin A can lead to Hypervitaminosis A characterised by fatigue, irritability, anorexia and weight loss, vomiting and gastro-intestinal disturbances, low-grade fever, skin changes, hair loss, dry hair, cracked and bleeding lips, anaemia, headache, hypercalcaemia, pains in bones and joints.

Symptoms of chronic toxicity in children may include raised intercranial pressure, and papilloedema mimicking brain tumours, tinnitus, visual disturbances and painful swelling over the long bones.

Symptoms usually clear on withdrawal of Vitamin A but in children premature closure of the epiphyses of the long bones may result in arrested growth. Acute Vitamin A intoxication may occur with very high doses and is characterised by sedation, dizziness, nausea and vomiting, erythema, pruritis and desquamation.

Overdosage with Vitamin B12 results in a bright yellow discoloration of the urine. Long-term overdosage with Vitamin B6 is associated with the development of severe peripheral neuropathies. Large doses of Vitamin C can cause diarrhoea and other gastro­intestinal disturbances.

Vitamin D: Excessive intake of Vitamin D leads to the development of hyper- calcaemia which is characterised by anorexia, nausea, vomiting, constipation, abdominal pain, muscle weakness, mental disturbances, polydipsia, polyuria, bone pain, nephrocalcinosis, renal calculi, and in severe cases cardiac arrhythmias and coma. Treatment is symptomatic and supportive.

Do not store above 30°C.

Protect from sunlight.

Keep out of reach of children.